Holy Family Church was constructed in 1883 at 915 North 18th Street, at the crossroads of 18th and Izard Streets in North Omaha, Nebraska. It is the oldest presented Catholic Church in Omaha, and is listed on the National Register of Historic Places. Holy Family Church was designed by local architects called the Cleves Brothers in Gothic Revival and Romanesque Revival Style in 1883. The complex includes a parish church, school and rectory built for Irish immigrants, and later serving Omaha's growing Italian immigrant community. Priests at Holy Family Church were ultimately responsible for establishing Creighton University in the late 1800s.There was also a priest assigned to serve the Omaha's Czech immigrant community in 1915.
Holy Family Church was regarded as a center of progressive activism in the 1960's and 70's under the pastorate of Father John McCaslin. David Rice, of the notorious Rice/Poindexter Case, was a guitar player at the church in the early 1970s.